Renal failure associated with ingestion of grapes and raisins in dogs

Yuk, Jin-yub; Kim, Cheol-ho; Kim, Tae-yung; Kang, Chung-boo

Korean Journal of Veterinary Research 2005;45(2):287-296.

Jin-yub Yuk¹, Cheol-ho Kim², Tae-yung Kim³, Chung-boo Kang¹

¹College of Veterinary Medicine, The Institute of Animal Medicine, Gyeongsang National University
²Gyeongsangnam-do Livestock Promotion Institute
³Animal Health Division, Ministry of Agriculture & Forestry

개에서 포도 및 건포도 섭취가 신부전에 미치는 영향

육진엽¹, 김철호², 김태융³, 강정부¹

¹경상대학교 수의과대학 동물의학연구소
²경상남도 축산진흥연구소
³농림부 가축방역과

Abstract

This experiments was designed to observe the effect of period and dose of ingestion of grapes on renal failure in dog. After the dogs had been mixed of general feed, raisins from U.S.A and fresh grapes from Chile selling in Korea. We observed the clinical sign, and analyzed the blood and urine using by biochemical test. The experiment was executed by the two following groups. The experiment group 1. derived renal failure by supplying the mixed general feed with fresh grapes and dry grapes 15 g per weight kg, 2 times a day (AM 09, PM 21), the experiment group 2. executed to derive renal failure by supplying the mixed general feed with fresh grapes and dry grapes 40 g per weight kg, 2 times a day. Extraction of blood for analysis was conducted one time a day and clinical test for renal failure was executed by means of a blood analysis, biochemical analysis, urine analysis, excretory urography (E.U) and E.R.D-$screen^{TM}$ urine test (Heska, USA). The results of group 1 were normal ranges (BUN 9.0~22.6 mg/dl, creatinine 0.8~1.2 mg/dl, Ca 9.7~12.3 mg/dl, Pi 2.9~4.6 mg/dl), renal failure was not observed. On the 3rd day in group 2, azotemia was arisen from the increasing BUN 83 mg/dl (7~25 mg/dl), creatinine 2.3 mg/dl (0.5~1.4 mg/dl), when executed urine was tested by E.R.D-$screen^{TM}$ test using in the early kidney disease diagnosis, microalbumine state was high positive, and it showed stale delay by using excretory urography (EU). This study demonstrated that acute renal failure by grapes and raisins dependent on food dose, and specific characters of individual.

Key Words: renal failure, grape, raisin, dog