| Effect of a trivalent (FPV, FHV, FCV) inactivated vaccine in kittens |
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Sung-min Lee1, In-joong Yoon2, Hwan-won Choi2, Keun-jwa Lee3, Kyoung-youl Lee4, Moo-kang Kim5 |
1Woosung Co., Ltd.
2ChoongAng Vaccine Laboratory
3Chungnam Livestock & Veterinary Service Institute
4Department of Anatomy and Neurobiology, Faculty of Medicine, Kagawa University
5College of Veterinary Medicine, Chungnam National University |
| 고양이 3종(FPV, FHV, FCV) 불활화 백신의 효과 |
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이성민1, 윤인중2, 최환원2, 이근좌3, 이경열4, 김무강5 |
1(주)우성양행
2(주)중앙백신연구소
3충남가축위생연구소
4일본 가가와대학
5충남대학교 수의과대학 |
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| Abstract |
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This study tested the effect of a trivalent (feline panleukopenia; FPV, feline viral rhinotracheitis; FHV, feline calicivirus infection; FCV) inactivated vaccine in cats. The vaccine was tested for the safety in guinea pigs, mice and cats. Also, it was tested for the efficacy in cats. The vaccine was inoculated to cats at 7~9 and 10~12 weeks of age (conventional schedule) and the serological response to vaccination was assessed and was compared to the unvaccinated group. All cats were bled by jugular venipuncture for FPV, FHV and FCV specific serological test (virus neutralizing antibody, VN) at 7~9, 10~12 and 13~15 weeks. After last bleeding, all cats were inoculated with each virus (FPV : orally $2ml;10^{7.5};TCID_{50}/ml$, FHV : nasally $1ml;10^{7.0};TCID_{50}/ml$ and FCV : nasally $1ml;10^{7.0};TCID_{50}/ml$). The Vaccine verified excellent protective effect in guinea pigs, mice and cats. The VN antibody titers of the unvaccinated group cats against FPV, FHV and FCV were <2~16, on the other hand the vaccinated group cats were $512{sim}{geq}4096$, 64~1024 and 64~1024, respectively. When all cats were challenged with virulent viruses, the survival rates of the vaccinated group cats were over 80%, while the survival rates of the unvaccinated group cats were less 20%. The typical clinical signs were not observed in the vaccinated group cats, but the typical clinical signs and histopathological lesions were observed in the unvaccinated group cats. As the result of tests, the VN values obtained in this study appeared to be high enough to protect cats from viral challenges. The trivalent (FPV, FHV, and FCV) inactivated vaccine seemed to be very effective, for prevention of feline viral diseases (FPV, FHV, and FCV). |
| Key Words:
vaccine effect, FPV, FHV, FCV, VN |
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