Antioxidative effects of Houttuynia cordata root on non-lipid oxidative damage

Hah, Dae-Sik; Kim, Chung-Hui; Kim, Euikyung; Kang, Chung-boo; Kim, Jong-shu

Korean Journal of Veterinary Research 2007;47(1):25-32.

Dae-Sik Hah¹, Chung-Hui Kim², Euikyung Kim³, Chung-boo Kang³, Jong-shu Kim³

¹Gyeongnam Livestock Promotion Institute Middle-branch
²Department of Animal Science and Biotechnology, Jinju National University
³College of Veterinary Medicine, Gyeongsang National University (Institute of Animal Science)

비 지질 산화손상에 대한 어성초 뿌리의 항산화 효과

하대식¹, 김충희², 김의경³, 강정부³, 김종수³

¹경상남도 축산진흥연구소 중부 지소
²진주산업대학교 동물생명과학과
³경상대학교 수의과대학 (동물의학연구소)

Abstract

Houttuynia cordata root on non-lipid oxidative damage. The antioxidative efects of methanolic (MeOH) extract of Houttuynia cordata rooton non-lipid, including liposome oxidation, oxidation of deoxyribose, protein oxidation, chelating, scavenging,and 2'-deoxyguanosine (2'dG) oxidation were investigated. Houttuynia cordata root exhibited highantioxidative effect in a liposome model system. The inhibitory effect of MeOH extract on deoxyribosedamage exhibited antioxidative effect and it afforded considerable protection against damage to deoxyribose.In addition, MeOH extract at over 300extracts exhibited metal binding ability for hydrogen peroxide. Furthermore, the oxidation of 2'dG to 8-hydroxy-2-deoxyguanosine was inhibited by MeOH extracts, and scavenging activity for hydroxyl radicalexhibited a remarkable effect. The present results on biological model systems showed that MeOH extractswas effective in the protection of non-lipids against various oxidative model systems.

Key Words: antioxidative effect, Houttuynia cordata root, non-lipid, oxidative damage