Korean Journal of Veterinary Research 2007;47(1):117-125.
Comparison of osteogenic efficacy depending on implant preparation in autograft
Jong-Il Lee1, Ha-Na Song2, Nam-soo Kim3, In-hyuk Choi3
1Graduate School of Agricultural and Life Sciences, The University of Tokyo
2Seosin Animal Hospital
3College of Veterinary Medicine, Chonbuk National University
자가골 이식에서 이식골편의 처리방법에 따른 골형성능력 비교
이종일1, 송하나2, 김남수3, 최인혁3
1동경대학교 농학생명과학대학원
2전주 서신동물병원
3전북대학교 수의과대학
Bone graft had been investigated previously to restore bone defects in orthopedics. The purpose of this study was to investigate the efficacy on new bone formation in bone autografts by treatment of implants. Cortical bone autografts were transplanted to midshaft of diaphyseal fibulae of 9 rabbits which were divided in 3 groups according to the treatment method of implants. Cortical bone implants for graft were treated with 3 different methods; freezing, freeze-drying, defat-freezing. Autografts were achieved by cross-transplantation method to bilateral fibulae of the presented rabbits after implant treatment procedures. The grafted regions of fibulae of all groups had been radiographed biweekly for 16 weeks to observe new bone formation and union between donor and recipient bone in the grafted region. Bone alkaline phosphatase (BALP) in all groups was evaluated biweekly till the end of the experiment to determine osteoblast activities. Unions of the experimental grafted regions were observed at 83% (5 of 6 cases) of freezing, 17% (1 of 6 cases) of freeze-drying and 67% (4 of 6 cases) of defat-freezing autografts, respectively. BALP was increased over 100% after 2 weeks of graft procedures in all union cases (all cases in freezing group and in defat-freezing group, and 1 of 3 in freeze-drying group, respectively), then gradually decreased from 4 th week of graft to 16 th week. In non-union cases, there is no significant variation in BALP value until the end of experiment. It is speculated that defat-freezing method of treatments of implants is more safe to preserve the osteogenic ability in autograft than freeze-drying method.
Key Words: BALP, bonegraft, defat-freezing, freeze-drying, freezing

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