Korean Journal of Veterinary Research 2007;47(2):197-202.
Larval migration inhibition activity of ivermectin, doramectin and ethanol against Anisakis simplex in vitro
Jae-Hyung Jeon, Cha-Ho Jee
College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University
시험관내에서 이버멕틴, 도라멕틴, 에타놀에 대한 아나사키스 유충의 운동성 억제효과
전재형, 지차호
충북대학교 수의과대학 및 동물의학연구소
Abstract
This experiment has been investigated in order to examine larval migration inhibition activity of ivermectin, doramectin and ethanol against Anisakis simplex (A. simplex) in vitro. A. simplex larvae were obtained from the mackerel acquired from the fish market of Cheongju. They were divided into many groups and placed in culture dishes (40 larvae each) containing RPMI-1640, in the absence or presence of different concentrations of ivermectin, doramectin and ethanol. Ivermectin had a complete inhibition of larval migration at 72 h in all groups ($10-300{mu}g/ml$). Ethanol reduced the migration of the larvae, its maximum activity being an high doses (7.5%, 10% ethanol) when it was 100% efficacy at 4 h. Doramectin had no efficacy in vitro. Being needed that further studies with ivermectin and doramectin, it is recommended that in vivo test with laboratory animals should be carried.
Key Words: Anisakis simplex, doramectin, ethanol, ivermectin, larval migration inhibition (LMI)
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