Korean Journal of Veterinary Research 2007;47(4):379-387.
Pathogenicity of Paenibacillus polymyxa JB115 and single-dose toxicity of its culture broth containing ${eta}$-glucan in rats
Hee-Kyoung Jung1, Eun-Hee Kang2, Zhi-Qiang Chang2, Joo-Heon Hong1, Sang-Dal Kim3, Byung-Kwon Park4, Hyo-In Yun5, Seung-Chun Park2
1Bio Industry Center, Daegu New Technology Agency
2College of Veterinary Medicine, Kyungpook National University
3College of Natural Resources, Yeungnam University
4Jeonjinbio
5College of Veterinary Medicine, Chungnam National University
Rat에서 Paenibacillus polymyxa JB115의 병원성 및 ${eta}$-glucan 함유 배양산물에 대한 단회 경구독성시험
정희경1, 강은희2, 챵즐치앙2, 홍주헌1, 김상달3, 박병권4, 윤효인5, 박승춘2
1대구바이오산업지원센터
2경북대학교 수의과대학
3영남대학교
4전진바이오팜
5충남대학교 수의과대학
Abstract
This study was conducted to investigate the pathogenicity of Paenibacillus (R) polymyxa JB 115 and single oral dose toxicity of culture broth containing (${eta}$-glucan (CBG-JB 115) produced from P. polymyxa JB 115 in Sprague-Dawely rats of both sexes for 14 days. After oral administration of P. polymyxa JB 115 into rats, we could not find any abnormal clinical signs and variation in the body weight and temperature as compared with control group. We also investigated the acute toxicity of CBG-JB 115. As the results, there were no clinical signs and variance in the body weight and temperature related with CBG-JB 115 in comparison with the control group. From the this experiment, we could not find out any significant pathogenicity and toxicity induced by P. polymyxa JB 115 or by CBG-JB 115. Results of this study demonstrated that consumption of P. polymyxa JB 115 and its culture broth containing (${eta}$-glucan was not associated with any obvious signs of toxicity in Sprague-Dawely rats even following consumption of large quantities.
Key Words: ${eta}$-glucan, Paenibacillus polymyxa, pathogenicity, single-dose toxicity


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