| Evaluation of antitumor. hepatoprotective and antimutagenic potentials of Phellinus gilvus |
|
Eun-Hee Kang, Kil-Soo Kim, Seung-Chun Park |
|
College of Veterinary Medicine, Kyungpook National University |
| Phellinus gilvus의 항암활성, 간보호 및 항돌연변이성에 대한 평가 |
|
강은희, 김길수, 박승춘 |
|
경북대학교 수의과대학 |
|
|
| Abstract |
|
This study was carried out to evaluate the antitumor, hepatoprotective and antimutagenic activities on hot water extract of Phellinus gilvus (PGE). Growth of tumor in mice that were orally given $0.25,0.5,1.0,2.0g;kg^{-1}$ dose of PGE was inhibited in a dose-dependent manner (p < 0.05). The hepatoprotective effect of PGE in the carbon tetrachloride ($CCl_4$)-intoxicated rats was studied. In $CCl_4$ + PGE group, PGE was orally administered with 100 mg/kg/day dose 7 days before the treatment of $CCl_4$. The serum activity of aspartate aminotransferase and alanine aminotransferase in $CCl_4$ + PGE group were decreased at a rate of 59.6% and 54.1% compared with those in $CCl_4$ group, respectively (p < 0.05). Also, total cholesterol and triglyceride in $CCl_4$ + PGE group were significantly decreased at a rate of 90% and 73.6% compared with those in $CCl_4$ group (p < 0.05). In the Ames test, we confirmed PGE doesn't have any activity as a mutant, and PGE showed inhibitory effect against mutagenesis induced by 2-amino fluride and sodium azide in Salmonella typhimurium TA98, TA100 and TA1535 in a dose-dependent manner. From the above results, we may suggest that PGE might have useful as a material for functional food and/or animal pharmaceutics. |
| Key Words:
antimutagenic effect, antitumor, hepatoprotective effect, Phellinus gilvus |
|
PDF Links
Full text via DOI
Download Citation
