Korean Journal of Veterinary Research 2008;48(1):17-26.
Evaluation of antitumor. hepatoprotective and antimutagenic potentials of Phellinus gilvus
Eun-Hee Kang, Kil-Soo Kim, Seung-Chun Park
College of Veterinary Medicine, Kyungpook National University
Phellinus gilvus의 항암활성, 간보호 및 항돌연변이성에 대한 평가
강은희, 김길수, 박승춘
경북대학교 수의과대학
Abstract
This study was carried out to evaluate the antitumor, hepatoprotective and antimutagenic activities on hot water extract of Phellinus gilvus (PGE). Growth of tumor in mice that were orally given $0.25,0.5,1.0,2.0g;kg^{-1}$ dose of PGE was inhibited in a dose-dependent manner (p < 0.05). The hepatoprotective effect of PGE in the carbon tetrachloride ($CCl_4$)-intoxicated rats was studied. In $CCl_4$ + PGE group, PGE was orally administered with 100 mg/kg/day dose 7 days before the treatment of $CCl_4$. The serum activity of aspartate aminotransferase and alanine aminotransferase in $CCl_4$ + PGE group were decreased at a rate of 59.6% and 54.1% compared with those in $CCl_4$ group, respectively (p < 0.05). Also, total cholesterol and triglyceride in $CCl_4$ + PGE group were significantly decreased at a rate of 90% and 73.6% compared with those in $CCl_4$ group (p < 0.05). In the Ames test, we confirmed PGE doesn't have any activity as a mutant, and PGE showed inhibitory effect against mutagenesis induced by 2-amino fluride and sodium azide in Salmonella typhimurium TA98, TA100 and TA1535 in a dose-dependent manner. From the above results, we may suggest that PGE might have useful as a material for functional food and/or animal pharmaceutics.
Key Words: antimutagenic effect, antitumor, hepatoprotective effect, Phellinus gilvus
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