Korean Journal of Veterinary Research 2008;48(1):27-32.
Development and sustained release effect of implantable formula of somatotropin
Nam-Joong Kim
Department of Companion Animal, Hyechon College
Somatotropin 이식 제형 개발과 지속적 방출 효과
김남중
혜천대학 애완동물과
Abstract
The present study was carried out to develop a sustained release implantable formula of bovine somatotropin (SRIF-BST) and to examine its sustained release effect. The SRIF-BST was produced by coating a solid pellet, which was comprised of BST and an excipient, made of a biodegradable polymer and poloxamer, which are capable of regulating the rate of BST release. The coated membrane of SRIFBST was observed with a field emission scanning electron microscope. The thickness of the coated membrane was approximately $1{mu}m$, and the pore sizes of the coated membrane surface were below $10{mu}m$. In dissolution test, the release duration of the SRIF-BST maintained for 10 days, whereas the release duration of the control BST formula maintained for 3 days. In weight gain assay and tibia test of hypophysectomized rats, the release duration of the SRIF-BST treated group was 12 days and the net weight gain was 53.16 g, also the tibia length and strength of the SRIF-BST treated group was increased 10.5% and 23.1% compared with those of the control group, respectively.
Key Words: hypophysectomized rat, somatotropin, sustained release implantable formula, SRIF


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