Korean Journal of Veterinary Research 2008;48(1):105-110.
Cerebrospinal fluid analysis in 13 clinically healthy Beagle dogs; hematological, biochemical and electrophoretic findings
Il-Hwan Kim1, Dong-In Jung1, Jong-Hyun Yoo2, Byeong-Teck Kang1, Chul Park3, Hee-Myung Park1
1College of Veterinary Medicine, Konkuk University
2BK21 Program of Integrative Network Systems for Veterinarians in Basic Science, Industrial Animals and Preventive Medicines, Konkuk University
3School of Veterinary Medicine, University of California
The purpose of this study is to define the normal findings of cerebrospinal fluid (CSF) of the clinically healthy Beagle dogs and to provide basic information in diagnosis of neurologic disorders. CSF obtained from 13 clinically healthy dogs was examined for total and differential cell counts, total protein concentration, glucose and lactate dehydrogenase (LDH) concentration, specific gravity, turbidity, and protein electrophoresis. On gross examination, CSF samples evaluated were clear and colorless. Few red blood cells and nucleated cells were present. The mean concentration of glucose and LDH examined were 65.8 mg/dl and 2.7 mg/dl, respectively. The cellular components of CSF samples based on differential counts were monocytes (41.9%), activated macrophages (35.8%), lymphocytes (20.0%), neutrophils (1.6%), and eosinophils (0.7%). The fractions of electrophoretic protein in CSF were albumin (52.7%), alpha-globulin (16.5%), beta-globulin (24.8%), and gamma-globulin (3.0%). Results of albumin quota were ranged from 0.15 to 0.38. In conclusion, this study provided normal composition of CSF in Beagle dogs.
Key Words: beagle dog, cerebrospinal fluid, CSF, cerebellomedullary cistern
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