Korean Journal of Veterinary Research 2008;48(1):111-117.
Medical imaging and immunohistochemical diagnosis of gastrointestinal stromal tumor originated from colon in a dog
Jihye Choi1, Hyunwook Kim1, Haekyung Lee1, Junyoung Kim2, Junghee Yoon2
1Haemaru Referral Animal Hospital
2College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University
개의 결장 간질종양에 대한 영상의학 및 면역조직화학 진단 1예
최지혜1, 김현욱1, 이혜경1, 김준영2, 윤정희2
1해마루 이차진료동물병원
2서울대학교 수의과대학 BK21 수의과학연구인력양성사업단
Gastrointestinal stromal tumor (GIST) is one of the mesenchymal tumors originated from gastrointestinal submucosa. A 10 year-old, male, mixed breed dog with persistent diarrhea, anorexia and lethargy was referred to Haemaru Animal Referral Hospital. Large mass originated from the transverse colon was observed and large amount of ascites and free gas were found on abdominal radiography and ultrasonography. The ascites was septic exudate mixed with bacteria that consisted with intestinal perforation. There was no metastatic lesion. This mass was tentatively diagnosed as adenocarcinoma, leiomyosarcoma (LMS) and lymphosarcoma and surgical resection and histilogical examination were planned. However, according to owner's request, the patient was euthanized and then the necropsy was performed. About 10 cm sized mass originated from the cecum, ascending colon and transverse colon was adhered to surrounding mesentery and the perforation and large amount of ascites were observed. GIST was suspected on histopathologic examination and confirmed according to CD 117 expression in immunohistochemistry. GIST, derived from interstitial cells of Cajal, can be distinguished from LMS and leiomyoma (LM) on the basis of expression of CD117 (KIT) immunohistochemically. GIST has a different biological behavior and clinical course compared with LMS and LM, therefore definite diagnosis for GIST using immunohistochemistry is clinically important to predict the precise prognosis of the patient.
Key Words: dog, gastrointestinal stromal tumor, mesenchymal, immunohistochemistry, CD117

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