Korean Journal of Veterinary Research 2008;48(3):305-310.
A case of transitional carcinoma in the nasal cavity of a dog
Hwa-Jung Kang1, Sang-Chul Kang2, Ji-Youl Jung1, Suk-Hee Jo1, In-Soon Roh3, Joo-Myung Lee1, Jongtae Cheong1, Jung-Hun Kim1, Min-Chan An4, Jong-Hee Bae1, Jae-Hoon Kim1
1College of Veterinary Medicine, Cheju National University
2Preclinical Research Center, Chemon Inc
3National Veterinary Research and Quarantine Service
4Halla Pet Hospital
개의 비강 내 이행암종 증례
강화정1, 강상철2, 정지열1, 조숙희1, 노인순3, 이주명1, 정종태1, 김정훈1, 안민찬4, 배종희1, 김재훈1
1제주대학교 수의과대학
2켐온 전임상 연구센터
A 10-year-old female Yorkshire terrier with the clinical signs of nasal swelling, epistaxis and nasal discharge was presented to the Veterinary Teaching Hospital in the Cheju National University. Abnormal nasal mass was detected in physical examination and radiographic findings. After surgical excision, the sample of nasal mass was referred to Pathology Department of Veterinary Medicine. Grossly, the mass was soft, friable, and $2.5{ imes}4cm$ cm in size. Histopathologically, the mass was composed of mediumsized non-keratinizing columnar to polyhedral cells arranged in anastomosing ribbon and large nest. It has complex in-folding of thick epithelial layers separated by fibrovascular septa. Tumor cells showed characteristic palisading arrangement of columnar cells, and perpendicularly distributed to the basement membrane. The cells had pale basophilic cytoplasm, oval nucleus and one or more nucleoli, and indistinct cellular border. Many tumor cell emboli were presented in lymphatics. Immunohistochemistry revealed that tumor cells were cytokeratin (CK) 19 and CK clone MNF116 positive and but CK7 and CK high molecular weight negative. Based on the gross, histopathologic, and immunohistochemical findings, the mass was diagnosed as transitional carcinoma in nasal cavity. In our best knowledge, this is the first report of transitional carcinoma originated from transitional zone of canine nasal cavity in Korea.
Key Words: cytokeratin, dog, immunohistochemistry, nasal cavity, transitional carcinoma

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