Korean Journal of Veterinary Research 2008;48(3):363-367.
A T-cell type multicentric Lymphoma affecting central nervous system in a Cocker Spaniel dog
Ju-Won Kim1, Dong-In Jung1, Byeong-Teck Kang1, Jong-Hyun Yoo2, Chul Park3, Dae-Young Kim4, Hee-Myung Park1
1College of Veterinary Medicine, Konkuk University
2BK21 Program of Integrative Network system for Veterinarians in Basic Science, Industrial Animals and Preventive Medicines, Konkuk University
3School of Veterinary Medicine, University of California
4College of Veterinary Medicine, University of Missouri-Columbia
A 4-year-old female Cocker spaniel was presented with respiratory distress and abdominal distension. Pleural effusion, ascites, hepatosplenomegaly, and superficial lymphadenopathy were observed and multicentric lymphoma was diagnosed by cytological examination. Immunophenotyping of lymph node and bone marrow using polymerase chain reaction for antigen receptor rearrangement identified a stage V lymphoma originating from T-cell. Despite of systemic chemotherapy using L-asparagenase, vincristine, cyclophoaphamide and prednisolone, neurologic deficits came out and progressed. Cerebrospinal fluid analysis revealed neoplastic lymphocytic pleocytosis indicating central nervous system involvement of lymphoma. The postmortem diagnosis was confirmed based on the histology and imunohistochemistry.
Key Words: central nervous system, dog, multicentric lymphoma, T-cell

Browse articles
For contributors
Editorial Office
#401-1, 85 Bldg., College of Veterinary Medicine, Seoul National University
1 Gwanak-ro, Gwanak-gu, Seoul 08826, Korea
Tel: +82-2-880-1229    Fax: +82-2-878-9762    E-mail: jvs@ksvs.or.kr                

Copyright © 2022 by The Korean Society of Veterinary Science.

Developed in M2PI

Close layer
prev next