| Effects of 2,3',4,4',5-pentachlorobiphenyl (PCB#118) on morphological changes in the rat testis |
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Gon-Sup Kim, Oh-Sung Park, Dae-Yong Han, Mun-Ki Kim, Phil-Ok Koh, Jae-Hyeon Cho, Soon-Bok Kim, Chung-Kil Won |
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Research Institute of Life Science and College of Veterinary Medicine, Gyeongsang National University |
| 2,3',4,4',5-pentachlorobiphenyl(PCB#118)가 랫드의 고환에 미치는 형태학적 변화 |
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김곤섭, 박오성, 한대용, 김문기, 고필옥, 조재현, 김순복, 원청길 |
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경상대학교 생명과학연구원 및 경상대학교 수의과대학 |
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| Abstract |
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This study was performed to examine the effect of 2,3',4,4',5-pentachlorobiphenyl (PCB#118) on testis of male rats. PCB#118 (20 mg/kg/week) in corn oil was intraperitoneally injected to adult male rats for 2, 5, 8 weeks. The body and testicular weights were measured at 3, 6, 9 weeks of PCB treatment. The morphological changes in the rat testes were then analyzed by light microscopy (LM) and transmission electron microscopy (TEM). The results showed that PCB#118 caused significant change in the body weights and testicular weights. Moreover, the morphological studies that were conducted on the PCB-treated rats revealed that the number of spermatocytes and spermatids in their seminiferous tubules decreased than control group (LM). The nuclear membrane was damaged when PCB was administered to them for 9 weeks (TEM). These results suggest that the reproductive function of the adult male rats is sensitive to PCB#118, and that may affect the testicular morphology of adult male rats. |
| Key Words:
morphology, polychlorinated biphenyl, testis |
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