Korean Journal of Veterinary Research 2008;48(4):393-399.
Radioprotective effect of fucoidan against hematopoietic and small intestinal stem cells of γ-ray irradiated mice
Eunjin Park, Seong Mo Jeon, Hong-Gu Joo, Kyu-Kye Hwang, Youngheun Jee
College of Veterinary Medicine and Applied Radiological Science Research Institute, Cheju National University
감마선을 조사한 마우스의 조혈 및 소장줄기세포에 대한 fucoidan의 방호효과
박은진, 전성모, 주홍구, 황규계, 지영흔
제주대학교 수의과대학
Abstract
We investigated the potential of fucoidan for its ability to provide protection from gamma rayinduced damage. In our results, the fucoidan significantly improved the counts of endogenous colony forming unit to $9.5 {pm} 1.5$, from $5.5 {pm} 2.5$ compared with un-treated irradiated control group at 10 day after 7 Gy whole body irradiation. After 2 Gy irradiation, fucoidan treatment attenuated the percent of tail DNA of splenocytes, parameters of DNA damage, from $30.17 {pm} 1.7%$ to $13.67 {pm} 2.81%$ 2.81% by comet assay and also accelerated the proliferation of splenocytes, compared with un-treated irradiated control group by 3Hthymidine incorporation assay. Furthermore, fucoidan decreased the number of apoptotic fragments per intestinal crypt by 31.8% at 1 days after 2 Gy irradiation. These results indicated that the fucoidan significantly improved the hematopoietic recovery, prevented the DNA damage in immune cells and enhanced their proliferation, which had been suppressed by ionizing radiation. in addition, fucoidan rescued intestinal cells from radiation-induced apoptosis. Thus, this study raises the possibility of using fucoidan as adjuvant therapeutic agent after radiotherapy.
Key Words: apoptosis, fucoidan, gamma-ray, hematopoiesis, mice


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