Korean Journal of Veterinary Research 2008;48(4):463-467.
A case of granulomatous meningoencephalomyelitis in a dog
Ji-Youl Jung1, Suk-Hee Jo1, Yoon-Ho Kang2, Jae-Hoon Kim1
1College of Veterinary Medicine, Cheju National University
2ShinJeju Animal Clinic
개의 육아종성 뇌수막척수염 증례 보고
정지열1, 조숙희1, 강윤호2, 김재훈1
1제주대학교 수의과대학
2신제주 동물병원
Granulomatous meningoencephalomyelitis (GME) is a sporadic, idiopathic, non suppurative inflammatory disease of the canine central nervous system. GME appears to have a worldwide distribution and to occur mostly in young to middle-age dogs of small breeds. A 6-year-old female mixed dog with wry neck, ataxia and rolling was submitted to the Cheju National University for diagnosis. Grossly, in the brain, cerebrospinal fluid was mildly increased and dilatation of the subarachnoid blood vessels was observed. Histopathologically, the lesions were characterized by perivascular cuffs of lymphocytes, various numbers of macrophages and plasma cells in the brainstem and cerebral white matter. Numerous granuloma composed of lymphocytes and histiocytes were scattered throughout the brainstem. Two malacic foci characterized by axonal swelling and gitter cell infiltration with hemorrhage were noted in the medulla oblongata and cerebellum. Special stains failed to demonstrate any infectious agents. Immunohistochemically, the infiltrated cells demonstrated strong positive reactions for CD3, a marker for T lymphocytes origin. Based on the clinical signs, histopathology, and immunohistochemistry, this case was diagnosed as GME in a mixed dog.
Key Words: CD3, dog, granulomatous meningoencephalomyelitis, immunohistochemistry, T lymphocyte

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