| Single-nucleotide polymorphisms in prion protein gene of the Korean subspecies of Chinese water deer |
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Hyun-Jeong Jeong1, Joong-Bok Lee1, Seung-Yong Park1, Chang-Seon Song1, Bo-Sook Kim2, Jung-Rae Rho2, Mi-Hyun Yoo2, Byung-Hoon Jeong3, Yong-Sun Kim3, In-Soo Choi1 |
1College of Veterinary Medicine, Konkuk University
2Seoul Grand Park Zoo
3Ilsong Institute of Life Science, Hallym University |
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| Abstract |
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Susceptibility to chronic wasting disease (CWD) in cervid species has been associated with polymorphisms in the prion protein gene (PRNP). The single nucleotide polymorphisms (SNPs) were found in the PRNP of the Korean subspecies of Chinese water deer via analyses of the DNA sequences obtained from 34 individual deer. Two SNPs were detected at codons 77 and 100. One SNP at codon 77 encoding Glycine was determined to be a silent mutation but the other SNP detected at codon 100 induced an amino acid change, from Asparagine to Serine. The prion protein (PrP) amino acid sequence of the water deer showed 98.8-99.2% homology with those of American elk, white-tailed deer and mule deer. The PrP of the water deer contained amino acid residues closely related with CWD-susceptibility. This study is the first to describe genetic variations in the PRNP of the Korean subspecies of Chinese water deer. |
| Key Words:
CWD, PRNP, SNP, susceptibility, water deer |
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