Korean Journal of Veterinary Research 2009;49(1):67-71.
Nasal adenocarcinoma in a dog
Jeong-Sik Yoon1, Ji-Youl Jung1, Suk-Hee Jo1, Jae-Hoon Kim1, Gye-Hyeong Woo2, Jae-Nam Jeon3, Jae-Hoon Kim1
1College of Veterinary Medicine, Jeju National University
2Disease Diagnostic Center, National Veterinary Research and Quarantine Service
3Kangnam Animal Hospital
개의 비강샘암종 증례
윤정식1, 정지열1, 조숙희1, 김재훈1, 우계형2, 전재남3, 김재훈1
1제주대학교 수의과대학
A 10-year old female Yorkshire terrier with nasal discharge and swelling was referred to the local animal hospital. Abnormal mass of right nasal cavity was detected in physical examination and radiography. According to the radiographs of the head, there was an evidence of bony destruction in right nose. Oronasal fistula was detected in right maxillary canine teeth. After surgical excision, the sample of nasal mass was refereed to Pathology Department of Veterinary Medicine in Jeju National University. Grossly, the enlarged mass was soft and 3 ${ imes}$ 3 cm in size. Histopathologically, the neoplastic mass was composed of tubular to tubulopapillary structures which were lined by single to 6~7 layers of cuboidal to ciliated columnar cells. These neoplastic cells showed invasive tendency to adjacent normal parenchyma. They had uniform, round to oval nuclei, cytoplasm with small vacuoles and indistinct cellular margin. The number of mitotic figures was varied in different areas, ranged from 0 to 4 per high power field. Necrotic foci and infiltration of inflammatory cells including neutrophils, lymphocytes, and plasma cells also presented in the mass. Immunohistochemically, the neoplastic cells demonstrated strong positive reaction for cytokeratin (CK) 18 but were negative for CK 7 and 8. Based on the gross, histopathology and immunohistochemistry, this mass was diagnosed as nasal adenocarcinoma originated from respiratory epithelium.
Key Words: adenocarcinoma, canine, cytokeratin, immunohistochemistry, nasal cavity

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