Nasal adenocarcinoma in a dog

Yoon, Jeong-Sik; Jung, Ji-Youl; Jo, Suk-Hee; Kim, Jae-Hoon; Woo, Gye-Hyeong; Jeon, Jae-Nam; Kim, Jae-Hoon

Korean Journal of Veterinary Research 2009;49(1):67-71.

Jeong-Sik Yoon¹, Ji-Youl Jung¹, Suk-Hee Jo¹, Jae-Hoon Kim¹, Gye-Hyeong Woo², Jae-Nam Jeon³, Jae-Hoon Kim¹

¹College of Veterinary Medicine, Jeju National University
²Disease Diagnostic Center, National Veterinary Research and Quarantine Service
³Kangnam Animal Hospital

개의 비강샘암종 증례

윤정식¹, 정지열¹, 조숙희¹, 김재훈¹, 우계형², 전재남³, 김재훈¹

¹제주대학교 수의과대학
²국립수의과학검역원
³강남동물병원

Abstract

A 10-year old female Yorkshire terrier with nasal discharge and swelling was referred to the local animal hospital. Abnormal mass of right nasal cavity was detected in physical examination and radiography. According to the radiographs of the head, there was an evidence of bony destruction in right nose. Oronasal fistula was detected in right maxillary canine teeth. After surgical excision, the sample of nasal mass was refereed to Pathology Department of Veterinary Medicine in Jeju National University. Grossly, the enlarged mass was soft and 3 ${ imes}$ 3 cm in size. Histopathologically, the neoplastic mass was composed of tubular to tubulopapillary structures which were lined by single to 6~7 layers of cuboidal to ciliated columnar cells. These neoplastic cells showed invasive tendency to adjacent normal parenchyma. They had uniform, round to oval nuclei, cytoplasm with small vacuoles and indistinct cellular margin. The number of mitotic figures was varied in different areas, ranged from 0 to 4 per high power field. Necrotic foci and infiltration of inflammatory cells including neutrophils, lymphocytes, and plasma cells also presented in the mass. Immunohistochemically, the neoplastic cells demonstrated strong positive reaction for cytokeratin (CK) 18 but were negative for CK 7 and 8. Based on the gross, histopathology and immunohistochemistry, this mass was diagnosed as nasal adenocarcinoma originated from respiratory epithelium.

Key Words: adenocarcinoma, canine, cytokeratin, immunohistochemistry, nasal cavity