Korean Journal of Veterinary Research 2009;49(1):73-78.
Discoid lupus erythematosus (DLE) in a juvenile Alaskan Malamute dog
Ha-Jung Kim1, Jong-Hyun Yoo1, Ju-Won Kim1, Chul Park2, Chae-Young Lim1, Jong-Hwan Lee1, Fu-Shi Quan3, Hee-Myung Park1
1College of Veterinary Medicine, Konkuk University
2School of Veterinary Medicine, University of California
3College of Medicine, The Catholic University of Korea
Abstract
Discoid lupus erythematosus (DLE) is an immune-mediated skin disease which requires histopathology and immunohistopathology in both dogs and humans. A 10-month-old, intact female Alaskan Malamute presented for depigmentation, swelling, alopecia, erythema, and crusting on the bridge of the nose and the nasal planum. Cytological examination of nasal lesions revealed numerous cocci and neutrophils. Histopathological features included of infiltration of mononuclear cells at the dermoepidermal junction. Direct immunofluorescence tests and immunohistochemistry exhibited positive IgG, IgM, IgA, CD3, CD18, and CD79a on the epidermal basement membranes and around adnexal glands. This case indicates both T cells and B cells are related to mechanism of canine DLE. This case report describes advanced diagnostic tests and clinical outcome with immune suppressive therapy in a rare juvenile canine DLE case.
Key Words: discoid lupus erythematosus, dog, immunohistochemistry, immunohistopathology
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