Korean Journal of Veterinary Research 2009;49(3):231-236.
Relationship between biofilm formation and the antimicrobial resistance in the Staphylococcus spp. isolated from animal and air
Yeon-Soo Seo, Deog Young Lee, Mi Lan Kang, Won Jung Lee, Han Sang Yoo
College of Veterinary Medicine, Brain Korea 21 Program for Veterinary Science and KRF Priority Zoonotic Disease Research Institute, Seoul National University
Biofilm has been described as a barrier, which produced by microorganisms to survive and protect themselves against various environments, like antibiotic agents. Staphylococcus spp. is a common cause of nosocomial and environmental infection. Thirty-six and thirty-five Staphylococci were isolated from animals and air, respectively. Based on the biofilm forming ability of the bacterium reported in our previous report, relationship between biofilm formation and antibiotic-resistance was investigated in this study. Regarding antibiotics susceptibility, cefazolin was the most effective agent to the bacteria. Strong biofilm-forming Staphylococcus spp. isolates might have a higher antibiotic resistance than weak biofilm isolates regardless of the presence of antibiotic resistance genes (p < 0.05). This result suggested that the chemical complexity of the biofilm might increase the antibiotic resistance due to the decrease of antibiotic diffusion into cells through the extensive matrix.
Key Words: antibiotic susceptibility, biofilm, Staphylococcus spp.

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