| Hyperinsulinism in a dog with beta-cell neoplasia (insulinoma) |
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Do-Hyeon Yu1, Jong-Hyun Lee1, Ru-Hui Song1, Dong-Ho Noh1, Ying-Hua Li1, Mi-Jin Lee1, Ara Cho2, Bumseok Kim2, Jinho Park1 |
1Department of Veterinary Internal Medicine, College of Veterinary Medicine, Chonbuk National University
2Department of Veterinary Pathology, College of Veterinary Medicine,Chonbuk National University |
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| Abstract |
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A six-year-old female cocker spaniel presented with recurring episodes of pelvic limb weakness and intermittent seizures. Laboratory analysis revealed marked hypoglycemia and an elevated serum insulin concentration. A pancreatic beta-cell tumor at stage III ($T_1N_1M_1$) was diagnosed based on serial blood glucose and insulin measurements along with diagnostic imaging. The patient survived for 140 days after diagnosis with medical management, including frequent feeding and prednisolone therapy. On necropsy, necrosis and masses in the peripancreatic omentum and liver were found; pancreatic beta-cell neoplasia with metastasis to the liver was confirmed by histopathologic examination. This case reports hyper-insulinism in a dog presenting with hypoglycemic seizures. |
| Key Words:
hypoglycemia, insulin-glucose ratio, insulin-secreting islet cell neoplasia, insulinoma, seizure |
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