Korean Journal of Veterinary Research 2010;50(3):247-251.
 Comparative study of wound healing in porcine urinary bladder with CO2 laser and scalpel incisions Jae-Yeon Lee1, Seong-Mok Jeong1, Sung-Whan Cho1, Chang-Sik Park2, Myung-Cheol Kim1 1College of Veterinary Medicine, Chungnam National University2Division of Animal Science & Resources, Research Center for Transgenic Cloned Pigs, Chungnam National University CO2 Laser와 Scalpel을 이용한 절개 시 돼지 방광에서의 창상치유 평가 이재연1, 정성목1, 조성환1, 박창식2, 김명철1 1충남대학교 수의과대학2충남대학교 동물자원학부, 형질전환 복제돼지 연구센터 Abstract This study compared the instrument performance and tissue healing of a steel scalpel with a $CO_2$ laser in an animal urinary bladder surgery model. Landrace and Yorkshire mixed breed pigs were used. Two symmetrical incisions were made in urinary bladder of each pig. One incision was made on the left side of ventral aspect on urinary bladder using a steel scalpel, while the other incision was performed on the right side using a $CO_2$ laser with an 8W output power. Each instrument was evaluated clinically for speed, ease of incision, and extent of bleeding. At 7 and 21 days after initial wounding, each wound was taken for histological observations. The scalpel was an easier instrument to use in the confines of the urinary bladder tissue, compared with the laser. However, there was no significant difference between the two groups. The amount of bleeding was less in the laser group but the time of the incisions was shorter with the scalpel. Scalpel incisions showed complete restoration of the epithelium and muscularis. On the other hand, the laser incisions showed incomplete restoration of the epithelium and muscularis. However, most of wound healing in the laser incisions was accomplished according to the time lapse. Although the scalpel produced less damage to the urinary bladder tissue and was easier to handle than the $CO_2$ laser, it did not provide hemostasis that was helpful for use on highly vascular tissue. The $CO_2$ laser provided good hemostasis, but delayed wound healing. In conclusion, the $CO_2$ laser provided better hemostasis and better surgical field than the scalpel. The $CO_2$ laser was used effectively in urinary bladder incision. Key Words: $CO_2$ laser, pig, scalpel, urinary bladder, wound healing

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