Korean J Vet Res > Volume 51(4); 2011 > Article
Korean Journal of Veterinary Research 2011;51(4):253-257.
DOI: https://doi.org/10.14405/kjvr.2011.51.4.253    Published online December 1, 2011.
Pharmacokinetics of amikacin in plasma of healthy goats after intravenous injection once daily for three days
Sania Naseem1, Mudasir Sultana1, Rajinder Raina1, Nrip Kishore Pankaj1, Pawan Kumar Verma1, Nasir Ahmad Nasir1, Azad Ahmad Ahanger2, Shafiqur Rahman3, Shahid Prawez1
1Divisions of Pharmacology and Toxicology, Faculty of Veterinary Sciences and Animal Husbandry, SKUAST-J
2Division of Pharmacology and Toxicology, Faculty of Veterinary Sciences and Animal Husbandry, SKUAST-Kashmir
3Divisions of Veterinary Pathology, Faculty of Veterinary Sciences and Animal Husbandry, SKUAST-J
Amikacin is a semisynthetic derivative of kanamycin and primarily active against aerobic Gram-negative-pathogens with limited activity against Gram-positive bacteria. Meager study was reported on pharmacokinetic data on multi-days administration of amikacin. Hence, pharmacokinetics study was done in five clinically healthy goats (n = 5), after intravenous bolus injection of amikacin sulfate at the dose rate of 10 mg/kg body weight daily for three consecutive days. The amikacin concentrations in plasma and pharmacokinetics-parameters were analyzed by using microbiological assay technique and noncompartmental open-model, respectively. The mean peak plasma concentrations (Mean ${pm}$ SD) of amikacin at time zero ($Cp^{0}$) was $114.19{pm}20.78$ and $128.67{pm}14.37{mu}g/mL$, on day 1st and 3rd, respectively. The mean elimination half-life ($t_{1/2}ke$) was $1.00{pm}0.28h$ on day 1st and $1.22{pm}0.29h$ on day 3rd. Mean of area under concentration-time curve ($AUC_{0{ ightarrow}{infty}}$) was $158.26{pm}60.10$ and $159.70{pm}22.74{mu}g.h/mL$, on day 1st and 3rd respectively. The total body clearance ($Cl_{B}$) and volume of distribution at steady state (Vdss) on day 1st and 3rd were $Cl_{B}=0.07{pm}0.02$ and $0.06{pm}0.01L/h.kg$ and $Vdss=0.10{pm}0.03$ and $0.11{pm}0.05L/kg$, respectively. No-significant difference was noted in both drug-plasma concentration and pharmacokinetics-parameters, respectively. Amikacin concentration in plasma was found higher up-to 4 h and 6 h onward on down-ward trends favour to reduce toxicity. Which also support the pharmacokinetic-pharmacodynamic way of dosing of aminoglycosides and hence, amikacin may be administered 10 mg/kg intravenously daily to treat principally Gram-negative pathogens and limitedly Gram-positive-pathogens.
Key Words: amikacin, intravenous bolus injection, pharmacokinetics, three days, 10 mg/kg

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