Korean J Vet Res > Volume 51(4); 2011 > Article
Korean Journal of Veterinary Research 2011;51(4):267-275.
DOI: https://doi.org/10.14405/kjvr.2011.51.4.267    Published online December 1, 2011.
Genetic characterization of methicillin-resistant Staphylococcus aureus from humans and animals within the community
Jae-Keun Cho1, Jin-Hyun Kim2, Myung-Suk Sung3, Ki-Seuk Kim4
1Metropolitan Health & Enviornmental Research Institute
2Gangwondo Veterinary Service Laboratory
3Gyeongbuk Veterinary Service Laboratory
4College of Veterinary Medicine, Kyungpook National University
지역사회 내 일반인 및 동물에서 methicillin 내성 Staphylococcus aureus의 유전학적 특성
조재근1, 김진현2, 성명숙3, 김기석4
1대구광역시보건환경연구원
2강원도가축위생시험소
3경상북도가축위생시험소
4경북대학교 수의과대학
Abstract
Methicillin-resistant Staphylococcus (S.) aureus (MRSA) is one of the most important nosocomial pathogens worldwide and the emergence of this strain has become a major clinical problem. In this study, we investigated the prevalence of MRSA and their genetic characteristics in 69 S. aureus isolated from humans and animals. In human isolates, higher antimicrobial resistance rates were observed against penicillin (80.6%), followed by erythromycin (11.9%) and tetracycline (9.0%). All of them were susceptible to clindamycin, enrofloxacin, novobiocin, pirlimycin, trimethoprim/sulfamethoxazole and vancomycin. The resistance patterns in animal isolates were similar to those of human isolates. Two (2.9%) MRSA strains were isolated from human (n = 1) and animal (n = 1), and these isolates were confirmed as carrying the mecA gene. One isolate originating from human was resistant to 7 drugs and the other isolate derived from animal was resistant to 11 drugs. Staphylococcal cassette chromosome mec (SCCmec) variant IIIB was identified in animal isolate but SCCmec type of an isolate from human was not exactly determined. Two MRSA isolates showed unrelated PFGE pattern between them. Our results indicated although the frequency of MRSA isolates from humans and animals was low, a continuous surveillance and monitoring should be called for to prevent the contamination and spread of MRSA in the community. To our knowledge, this is the first time that SCCmec type variant IIIB was detected from animals in Korea.
Key Words: mecA gene, MRSA, PFGE, SCCmec type


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