Studies on the anti-parasitic efficacy and safety of ivermectin and pyrantel pamoate compound against Dirofilaria immitis in dogs

Youn, Heejeong; Ra, Jeong-Chan; Kim, Byung-Ki; Lim, Yong-Suk; Kim, Kyong-Hee; Lee, Kyong-Eun

doi:2012.52.1.53

Korean J Vet Res > Volume 52(1); 2012 > Article

Original Article

Korean Journal of Veterinary Research 2012;52(1):53-56.
DOI: https://doi.org/10.14405/kjvr.2012.52.1.053 Published online March 31, 2012.

Studies on the anti-parasitic efficacy and safety of ivermectin and pyrantel pamoate compound against Dirofilaria immitis in dogs

Heejeong Youn¹, Jeong-Chan Ra², Byung-Ki Kim², Yong-Suk Lim¹, Kyong-Hee Kim¹, Kyong-Eun Lee¹

¹College of Veterinary Medicine, Seoul National University
²RNL-Bio

Abstract

Dirofilaria (D.) immitis is an important canine parasitic nematode in dogs. D. immitis parasitizes the right ventricle and pulmonary artery of dogs. An ivermectin and pyrantel pamoate compound (IPPC) was administered to dogs naturally infected with this parasite. IPPC is composed of 68.0, 136.0 and $272.0{mu}g$ of ivermectin and 57.0, 114.0 and 227.0 mg pyrantel pamoate for small, middle, and large animals. Ivermectin has activity against nematodes and ectoparasites in dogs. Pyrantel pamoate is also effective against nematodes in dogs. Our results showed that this drug combination has good efficacy in D. immitis infected dogs.

Key Words: Dirofilaria immitis, ivermectin, ivermectin and pyrantel pamoate compound, pyrantel pamoate