Korean J Vet Res > Volume 52(3); 2012 > Article
Korean Journal of Veterinary Research 2012;52(3):157-162.
DOI: https://doi.org/10.14405/kjvr.2012.52.3.157    Published online September 30, 2012.
Safety and outcomes of subconjunctival allogenic mesenchymal stem cell transplantation in canine experimental corneal defects
Ju-Won Kim, So-Young Lee, Hee-Myung Park
Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University
Corneal injury is very common clinical condition in veterinary medicine and delayed or incomplete corneal healing has the potential of vision loss due to the loss of corneal transparency. For the reconstruction of corneal epithelium, tissue graft and cell transplantation have been prosperously investigated. The purpose of this study was to evaluate the clinical value and short-term safety of application of cultured allogenic mesenchymal stem cells (MSCs) in the treatment of canine experimental corneal defect. Corneal defects were surgically generated in the central corneas of healthy beagle dogs and cultured canine allogenic MSCs were transplanted via subconjunctival injection. Although mean healing time, the rate of epithelial regeneration, and the degree of corneal transparency were not significantly improved after MSC transplantation, significant immune reaction or incompatibility reaction was not detected except transient local irritation. These results propose the possibility of MSC application as a new regenerative medicine in canine ocular disorders.
Key Words: cornea, dogs, mesenchymal stem cell, transparency
METRICS Graph View
  • 1 Crossref
  •  0 Scopus
  • 564 View
  • 6 Download
Related articles

Browse articles
For contributors
Editorial Office
#401-1, 85 Bldg., College of Veterinary Medicine, Seoul National University
1 Gwanak-ro, Gwanak-gu, Seoul 08826, Korea
Tel: +82-2-880-1229    Fax: +82-2-878-9762    E-mail: jvs@ksvs.or.kr                

Copyright © 2023 by The Korean Society of Veterinary Science.

Developed in M2PI

Close layer
prev next