Korean J Vet Res > Volume 52(3); 2012 > Article
Korean Journal of Veterinary Research 2012;52(3):199-203.
DOI: https://doi.org/10.14405/kjvr.2012.52.3.199    Published online September 30, 2012.
An immunohistochemical study on the initial development of 155 kd neurofascin in rat sciatic nerve
Hee-Young Won1, Ik-Hyun Cho2, Jong-Hwan Lee1, Sang-Soep Nahm1, Nong-Hoon Choe1, Jae-Hyung Park2, Byung-Joon Chang1
1College of Veterinary Medicine and Veterinary Research Institute, Konkuk University
2School of Medicine, College of Oriental Medicine, Kyunghee University
랫드 궁둥신경에서 155 kd Neurofascin의 발현개시에 대한 면역세포화학적연구
원희영1, 조익현2, 이종환1, 남상섭1, 최농훈1, 박재형2, 장병준1
1건국대학교 수의과대학 및 수의과학연구소
2경희대학교 한의과대학
Abstract
Neurofascin, one of the members of L1CAM, has been known to have some important roles during the development of nerve fibers. In order to investigate the role of neurofascin associated with the development of nerve fibers in the rat sciatic nerve, the initial development of NF155 in the paranode was studied with immuno-fluorescence and immuno-electron microscopy. The result of the present study showed NF155 was not detected in the fetal sciatic nerve and began to reveal at the postnatal day 0 (P0) and dramatically increased by time lapse until postnatal day 7 (P7). NF155 was prominently localized in the axolemma of paranode and not detected in the central region of node of Ranvier. According to the present study, NF155 is likely to have some relationships with the formation of paranode and myelin sheath.
Key Words: immunocytochemistry, NF155, paranode, sciatic nerve


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