Korean J Vet Res > Volume 52(4); 2012 > Article
Korean Journal of Veterinary Research 2012;52(4):275-280.
DOI: https://doi.org/10.14405/kjvr.2012.52.4.275    Published online December 31, 2012.
Anti-oxidant activities of kiwi fruit extract on carbon tetrachloride-induced liver injury in mice
Wonyoung Kang, Heekyoung Yang, Hyun Ju Hong, Chang Hoon Han, Young Jae Lee
College of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University
The kiwi (Actinidia deliciosa) is well known to contain anti-oxidants. In this study, we investigated the anti-oxidant effects of kiwi extract on carbon tetrachloride ($CCl_4$) induced liver injury in BALB/c mice. The radical scavenging effect of 80% methanol extract of Halla-Gold kiwi was observed. For the animal study, mice were randomly divided into four groups: normal group, $CCl_4$-induced model group, kiwi extract administered group, and silymarin treated group. The kiwi extract was provided daily for 10 days. At the 24 h after last administration, $CCl_4$ was injected. The kiwi extract showed strong inhibitory effect of DPPH radicals and superoxide scavenging. In animal study, administration of $CCl_4$ resulted in significantly elevated plasma levels of ALT and AST but they decreased in kiwi-extract pretreated group. Anti-oxidant enzymes such as GSH-px and GSH-rd were restored in the kiwi extract treatment group. Histopathological degeneration was also prevented in the kiwi extract treated group compared with of the control group, which exhibited $CCl_4$-induced hepatotoxicity. On the basis of the obtained results, it can be concluded that kiwi extract showed protective effects, not only as anti-oxidant effects, but also in the protection of hepatotoxicity in $CCl_4$-intoxicated mice.
Key Words: antioxidant, carbon tetrachloride, cytochrome P450 2E1, hepatotoxicity, kiwi fruit

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