| Efficacy and clinical trials of Salenvac-T, bivalent killed vaccine containing Salmonella Enteritidis and Salmonella Typhimurium |
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Youngjae Cho1, Zheng-Wu Kang1, Kyung-Soo Kang2, Seunghwan Jeong3, Hee-Jun Yoon4, Seungwon Suh3, Tae-Wook Hahn1 |
1College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University
2Dongducheon Bayel Animal Clinic
3Intervet (MSD AH) Korea
4Kangwon Veterinary Clinic |
| Salmonella Enteritidis 및 Salmonella Typhimurium을 함유한 이가 불활화백신인 Salenvac-T의 방어효과 및 임상연구 |
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조영재1, 강정무1, 강경수2, 정승환3, 윤희준4, 서승원3, 한태욱1 |
1강원대학교 수의과대학 및 동물의학종합연구소
2동두천바이엘
3인터베트코리아(주)
4강원가축병원 |
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| Abstract |
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Commercial bivalent killed Salmonella vaccine Salenvac-T has been used in several countries in order to prevent salmonellosis with Salmonella enterica serovars Enteritidis (SE) and Typhimurium (ST) in poultry. However, this vaccine has not been used in poultry farms in South Korea. In this study, we evaluated the efficacy of Salenvac-T vaccine to protect against the challenge of virulent SE and ST, and the effect of the vaccine on egg production and mortality in layer hens. The colonization of liver, spleen and cecum with challenged SE and ST was reduced in vaccinated chickens compared with that of unvaccinated control group. The twice vaccination with Salenvac-T induced elevated antibody responses against both SE and ST detected by enzyme-linked immunosorbent assay (ELISA). The higher average hen-day production was observed in the vaccinated layer hens than in the unvaccinated layer hens without significance. The average mortality was lower in the vaccinated layer hens during the experiment period. The antibody responses to both SE and ST were persistently detected in the vaccinated layers. In summary, vaccination with Salenvac-T reduces colonization of internal organs and induces good antibody responses, thereby results in higher performance and lower egg contamination with SE and ST in layer hens. |
| Key Words:
bivalent killed vaccine, efficacy, layers, performance, Salenvac-T |
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