Korean J Vet Res > Volume 53(3); 2013 > Article
Korean Journal of Veterinary Research 2013;53(3):159-162.
DOI: https://doi.org/10.14405/kjvr.2013.53.3.159    Published online September 26, 2013.
Immunohistochemical localization of galectin-3 in the brain with Theiler's murine encephalomyelitis virus (DA strain) infection
Taekyun Shin1, Francisco J. Carrillo-Salinas2, Ana Feliu Martinez2, Miriam Mecha2, Carmen Guaza2
1Department of Veterinary Anatomy, College of Veterinary Medicine, Jeju National University
2Department of Functional and Systems Neurobiology, Neuroimmunology Group, Instituto Cajal, CSIC
Galectin-3 is a ${eta}$-galactoside-binding lectin that plays a role in neuroinflammation through cell migration, proliferation, and apoptosis. In the present study, regulation of galectin-3 was examined in the brain of mice infected with the Daniel strain of Theiler's murine encephalomyelitis virus (TMEV) at days 7 and 81 post-infection by immunohistochemistry. Immunohistochemistry revealed that galectin-3 was mainly localized in ionized calcium-binding adapter 1-positive macrophages/activated microglia, but not in Iba-1-positive ramified microglia. Galectin-3 was also weakly detected in some astrocytes in the same encephalitic lesions, but not in neurons and oligodendrocytes. Collectively, the present findings suggest that galectin-3, mainly produced by activated microglia/macrophages, may be involved in the pathogenesis of virus induced acute inflammation in the early stage as well as the chronic demyelinating lesions in Daniel strain of TMEV induced demyelination model.
Key Words: encephalomyelitis, galectin-3, macrophages, microglia, Theiler's murine encephalomyelitis virus

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