| Protective effects of a mineral aqueous solution on toxicity in mouse liver and kidney |
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In-Jae Park, Se-Yeoun Cha, Min Kang, Yang-Sub So, Ji-Yun Bahng, Hyung-Kwan Jang |
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Department of Veterinary Infectious Diseases and Avian Diseases, College of Veterinary Medicine & Korea Zoonosis Research Institute, Chonbuk National University |
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| Abstract |
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We demonstrated that a mineral aqueous solution (MAS) administered to mice functionally and histologically protected against cisplatin-induced acute renal failure (ARF) and $CCl_4$-induced acute liver failure (ALF). In ARF model, 0.4 and 0.2% MAS decreased mortality and the serum concentrations of blood urea nitrogen (BUN) and creatine in mice. Additionally, 0.4 and 0.2% MAS reduced contraction of distal convoluted tubules and suppressed expression of the proinflammatory cytokines interlukein-6 (IL-6) and tumor necrosis factor (TNF-${alpha}$) in the kidney. In ALF model, 0.4 and 0.2% MAS decreased serum concentrations of alanine aminotransferase and aspartate aminotransferase in mice. Additionally, 0.4 and 0.2% MAS reduced necrotic areas and suppressed expression of IL-6 and TNF-${alpha}$ in the liver. These results indicate that a MAS might have protective effects against ARF and ALF. |
| Key Words:
$CCl_4$-induced acute liver failure, cisplatin-induced acute renal failure, mineral aqueous solution, silicon |
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