Korean J Vet Res > Volume 53(3); 2013 > Article
Korean Journal of Veterinary Research 2013;53(3):169-174.
DOI: https://doi.org/10.14405/kjvr.2013.53.3.169    Published online September 26, 2013.
Protective effects of a mineral aqueous solution on toxicity in mouse liver and kidney
In-Jae Park, Se-Yeoun Cha, Min Kang, Yang-Sub So, Ji-Yun Bahng, Hyung-Kwan Jang
Department of Veterinary Infectious Diseases and Avian Diseases, College of Veterinary Medicine & Korea Zoonosis Research Institute, Chonbuk National University
We demonstrated that a mineral aqueous solution (MAS) administered to mice functionally and histologically protected against cisplatin-induced acute renal failure (ARF) and $CCl_4$-induced acute liver failure (ALF). In ARF model, 0.4 and 0.2% MAS decreased mortality and the serum concentrations of blood urea nitrogen (BUN) and creatine in mice. Additionally, 0.4 and 0.2% MAS reduced contraction of distal convoluted tubules and suppressed expression of the proinflammatory cytokines interlukein-6 (IL-6) and tumor necrosis factor (TNF-${alpha}$) in the kidney. In ALF model, 0.4 and 0.2% MAS decreased serum concentrations of alanine aminotransferase and aspartate aminotransferase in mice. Additionally, 0.4 and 0.2% MAS reduced necrotic areas and suppressed expression of IL-6 and TNF-${alpha}$ in the liver. These results indicate that a MAS might have protective effects against ARF and ALF.
Key Words: $CCl_4$-induced acute liver failure, cisplatin-induced acute renal failure, mineral aqueous solution, silicon

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