Korean J Vet Res > Volume 53(3); 2013 > Article
Korean Journal of Veterinary Research 2013;53(3):189-192.
DOI: https://doi.org/10.14405/kjvr.2013.53.3.189    Published online September 26, 2013.
Metastatic thyroid C-cell carcinoma in a beagle dog
So-Ra Lee1, Mi-Kyoung Lee1, Kyoung-A Youp1, Ah-Ra Lee1, Sung-Jun Won1, Myung-Chul Kim2, So-Yeon Kim2, Yongbaek Kim2
1Irion Animal Hospital
2The Laboratory of Clinical Pathology, College of Veterinary Medicine, Seoul National University
Abstract
An adult beagle dog was presented with a cervical mass detected by palpation and computed tomography. Fine needle aspirates revealed numerous epithelial cells with plasmacytoid appearance and frequent naked nuclei. Histologically, the mass consists of multiple packets of neoplastic cells and extensive areas of necrosis and fibrosis. Neoplastic cells were also found in submandibular lymph nodes. Immunohistochemistry showed that neoplastic cells were positive for calcitonin and negative for thyroglobulin. Based on these findings, the cervical mass was diagnosed as thyroid C-cell carcinoma. Almost one year after the surgical excision, the dog remains healthy without any symptom of recurrence or metastasis.
Key Words: calcitonin, C-cell carcinoma, dog, metastasis, thyroid


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