Korean J Vet Res > Volume 54(3); 2014 > Article
Korean Journal of Veterinary Research 2014;54(3):139-146.
DOI: https://doi.org/10.14405/kjvr.2014.54.3.139    Published online September 24, 2014.
Bacterial strains isolated from Jeotgal (salted seafood) induce maturation and cytokine production in mouse bone marrow-derived dendritic cells
Sun-Young Moon1, Eun-Jin Park2, Hong-Gu Joo1
1Laboratory of Veterinary Pharmacology, College of Veterinary Medicine, Jeju National University
2Department of Food Bioengineering, College of Engineering, Jeju National University
마우스 골수 유래 수지상세포의 성숙과 사이토카인 생산에 대한 젓갈 분리균의 효과 연구
문선영1, 박은진2, 주홍구1
1제주대학교 수의과대학 수의약리학실
2제주대학교 공과대학 식품생명공학과
Abstract
Jeotgal (salted seafood) has been one of major fermented foods in Korea for long time. Although there are many studies about Jeotgal in various aspects of food, its immunological importance on hosts has not been elucidated yet. In this study, we investigated if several bacteria isolated from Jeotgal may modulate the function of dendritic cells (DCs), powerful antigen-presenting cells equipped with special immunological capabilities. 4 Jeotgal bacteria were selected as representatives and used for experiments. To treat viable DCs, those bacteria were killed at $60^{circ}C$ for 30 min. The viability of DCs treated with Jeotgal bacteria was verified and two isolates significantly induced high production of interleukin-12, a representative cell-mediated cytokine of DCs. Surface activation and maturation markers (MHC class II, CD40, CD86) of DCs were analyzed by flow cytometer. In addition, the treated DCs showed significantly high lymphocyte stimulatory capability compared to control DCs based on allogeneic mixed lymphocyte reactions. These observations suggest that Jeotgal isolates can function as immunostimulating bacteria in hosts, like Lactobacillus. Taken together, these experimental evidences may broaden the use of Jeotgal isolates in immunological fields in addition to as a fermented food.
Key Words: dendritic cells, immunostimulation, Jeotgal isolates (microorganisms), probiotics
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