Korean J Vet Res > Volume 54(3); 2014 > Article
Korean Journal of Veterinary Research 2014;54(3):189-192.
DOI: https://doi.org/10.14405/kjvr.2014.54.3.189    Published online September 24, 2014.
Antibacterial and therapeutic effects of a combination of Sophora flavescens and Glycyrrhiza uralensis Fischer ethanol extracts on mice infected with Streptococcus pyogenes
Eun-Ah Yu1, Chun-Nam Cha2, Eun-Kee Park3, Chang-Yeul Yoo4, Suk Kim5, Hu-Jang Lee6
1Tongyeong National Quarantine Station, Ministry of Health & Welfare
2Department of Industrial Systems Engineering, Engineering Research Institute, Gyeongsang National University
3Department of Medical Humanities and Social Medicine, College of Medicine, Kosin University
4Department of Computer Information, Gyeongnam Provincial Namhae College
5College of Veterinary Medicine, Research Institute of Live Sciences, Gyeongsang National University
6Graduate School of Public Health, Gyeongsang National University
Abstract
This study evaluated the antibacterial effects of a mixture of Sophorae radix and Glycyrrhiza uralensis Fischer (1 : 1) ethanol extracts (SGE) on mice infected with Streptococcus (S.) pyogenes. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration of SGE necessary for antibacterial effects against S. pyogenes were $20{mu}g/mL$. Based on the time-kill curves for S. pyogenes, SGE was effective at $4{ imes}$ MIC after 16 h. On Day 12 after challenge, the survival rate of mice treated with 2.0 mg/kg SGE was 60%. In conclusion, SGE had potent in vitro and in vivo antibacterial activities against S. pyogenes.
Key Words: crude extracts, medicinal plants, mice, Streptococcus pyogenes, treatment efficacy


About
Browse articles
For contributors
Policy
Editorial Office
#401-1, 85 Bldg., College of Veterinary Medicine, Seoul National University
1 Gwanak-ro, Gwanak-gu, Seoul 08826, Korea
Tel: +82-2-880-1229    Fax: +82-2-878-9762    E-mail: jvs@ksvs.or.kr                

Copyright © 2024 by The Korean Society of Veterinary Science.

Developed in M2PI

Close layer
prev next