Korean J Vet Res > Volume 54(4); 2014 > Article
Korean Journal of Veterinary Research 2014;54(4):203-208.
DOI: https://doi.org/10.14405/kjvr.2014.54.4.203    Published online December 22, 2014.
Stimulatory effects of Bordetella bronchiseptica antigen on bone marrow cells and immune memory responses
Seol-Hwa Yim, Hong-Gu Joo
Laboratory of Veterinary Pharmacology, College of Veterinary Medicine, Jeju National University
골수세포에 대한 Bordetella bronchiseptica 항원의 자극 효과 및 면역기억반응
임설화, 주홍구
제주대학교 수의과대학 수의약리학실
Abstract
Bone marrow is a hematological and immunological organ that provides multiple immune cells, including B lymphocytes, and thus plays a critical role in the efficacy of vaccine. We previously demonstrated that Bordetella (B.) bronchiseptica antigen has high immunogenicity in spleen cells, a peripheral immune organ. In this study, we investigated the immunogenicity of B. bronchiseptica antigen in bone marrow cells, a central immune organ. B. bronchiseptica antigen increased the cellular activity of bone marrow cells and significantly enhanced the production of nitric oxide, IL-6, and TNF-${alpha}$. Bone marrow cells primed with B. bronchiseptica antigen in vivo were harvested and stimulated with the same antigen in vitro. The stimulation of B. bronchiseptica antigen significantly increased the cellular activity and proliferation rate of the primed cells. B. bronchiseptica antigen also greatly induced the production of antigen-specific antibody in the primed cells. Taken together, the present study demonstrated that B. bronchiseptica antigen can stimulate bone marrow cells, a central immune organ, and recall the immune response of the primed bone marrow cells.
Key Words: antigen, Bordetella bronchiseptica, immune memory responses, stimulatory effects, vaccine


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