Korean J Vet Res > Volume 54(4); 2014 > Article
Korean Journal of Veterinary Research 2014;54(4):245-252.
DOI: https://doi.org/10.14405/kjvr.2014.54.4.245    Published online December 22, 2014.
Evaluation of thermally cross-linked superparamagnetic iron oxide nanoparticles for the changes of concentration and toxicity on tissues of Sprague-Dawley rats
Jin Joo Hue1, Hu-Jang Lee2, Sangyong Jon3, Sang Yoon Nam1, Young Won Yun1, Jong-Soo Kim1, Beom Jun Lee1
1College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University
2College of Veterinary Medicine and Research Institute of Life Science, Gyeongsang National University
3School of Life Science, Gwangju Institute of Science and Technology
Abstract
This study was investigated the change of concentration and toxicity of thermally cross-linked superparamagnetic iron oxide nanoparticles (TCL-SPION) on tissues of Sprague-Dawley rats. TCL-SPION at the dose of 15 mg/kg body weight was intravenously injected into the tail vein of the male Sprague-Dawley rats. The fate of TCL-SPION in serum, urine and tissues was observed during 28 days. Serum iron level was maximal at 0.25 h post-injection and gradually declined thereafter. In addition, the sinusoids of liver and the red pulp area of spleen were mainly accumulated iron from 0.5 h to 28-day post-injection. In kidney, iron deposition was detected in the tubular area until 0.5 h after injection. Malondialdehyde concentration in the liver slightly increased with time and was not different with that at zero time. In the liver and spleen, TNF-${alpha}$ and IL-6 levels of TS treated with TCL-SPION were not different with those of the control during the experimental period. From the results, TCL-SPION could stay fairly long-time in certain tissues after intravenous injection without toxicity. The results indicated that TCL-SPION might be useful and safe as a contrast for the diagnosis of cancer or a carrier of therapeutic reagents to treat diseases.
Key Words: accumulation, biodistribution, rats, thermally cross-linked superparamagnetic iron oxide nanoparticles, toxicity


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