Korean J Vet Res > Volume 55(1); 2015 > Article
Korean Journal of Veterinary Research 2015;55(1):57-60.
DOI: https://doi.org/10.14405/kjvr.2015.55.1.57    Published online March 24, 2015.
Distribution and accumulation of 177Lu-labeled thermally cross-linked superparamagnetic iron oxide nanoparticles in the tissues of ICR mice
Jin Joo Hue1, Hu-Jang Lee2, Sang Yoon Nam1, Jong-Soo Kim1, Beom Jun Lee1, Young Won Yun1
1College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University
2College of Veterinary Medicine and Institute of Life Science, Gyeongsang National University
Abstract
To investigate kinetics of free $^{177}Lu$ and $^{177}Lu$-labeled thermally cross-linked superparamagnetic iron oxide nanoparticles (TCL-SPION), suspensions were intravenously injected into the tail vein of mice at a dose of $5{mu}Ci$/mouse or 15 mg/kg body weight, respectively. Free $^{177}Lu$ radioactivity levels were highest in kidney followed by liver and lung 1 day post-injection. $^{177}Lu$-labeled TCL-SPION radioactivity in liver and spleen was significantly higher compared to that of other organs throughout the experimental period (p < 0.05). Radioactivity in blood, brain, and epididymis rapidly declined until 28 days. Based on these results, TCL-SPION could be a safe carrier of therapeutics.
Key Words: accumulation, biodistribution, $^{177}Lu$, nanotoxicity, TCL-SPION


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