Distribution and accumulation of <sup>177</sup>Lu-labeled thermally cross-linked superparamagnetic iron oxide nanoparticles in the tissues of ICR mice

Hue, Jin Joo; Lee, Hu-Jang; Nam, Sang Yoon; Kim, Jong-Soo; Lee, Beom Jun; Yun, Young Won

doi:2015.55.1.57

Korean J Vet Res > Volume 55(1); 2015 > Article

Brief Communication

Korean Journal of Veterinary Research 2015;55(1):57-60.
DOI: https://doi.org/10.14405/kjvr.2015.55.1.57 Published online March 24, 2015.

Distribution and accumulation of ¹⁷⁷Lu-labeled thermally cross-linked superparamagnetic iron oxide nanoparticles in the tissues of ICR mice

Jin Joo Hue¹, Hu-Jang Lee², Sang Yoon Nam¹, Jong-Soo Kim¹, Beom Jun Lee¹, Young Won Yun¹

¹College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University
²College of Veterinary Medicine and Institute of Life Science, Gyeongsang National University

Abstract

To investigate kinetics of free $^{177}Lu$ and $^{177}Lu$-labeled thermally cross-linked superparamagnetic iron oxide nanoparticles (TCL-SPION), suspensions were intravenously injected into the tail vein of mice at a dose of $5{mu}Ci$/mouse or 15 mg/kg body weight, respectively. Free $^{177}Lu$ radioactivity levels were highest in kidney followed by liver and lung 1 day post-injection. $^{177}Lu$-labeled TCL-SPION radioactivity in liver and spleen was significantly higher compared to that of other organs throughout the experimental period (p < 0.05). Radioactivity in blood, brain, and epididymis rapidly declined until 28 days. Based on these results, TCL-SPION could be a safe carrier of therapeutics.

Key Words: accumulation, biodistribution, $^{177}Lu$, nanotoxicity, TCL-SPION