Korean J Vet Res > Volume 55(2); 2015 > Article
Korean Journal of Veterinary Research 2015;55(2):111-116.
DOI: https://doi.org/10.14405/kjvr.2015.55.2.111    Published online June 24, 2015.
Influence of various photoperiods on stress hormone production, immune function, and hematological parameters in ICR mice
Seung-Hyu Park1, Il-Gyue Kim1, Hyung-Chan Kim1, Mi-Jeong Gang1, Song-Ee Son2, Hu-Jang Lee2
1Uiryeong High School
2College of Veterinary Medicine and Research Institute of Life Sciences, Gyeongsang National University
광주기 변화에 따른 마우스의 스트레스 호르몬, 면역기능 및 혈액학적 지표에 미치는 영향
박승휴1, 김일규1, 김형찬1, 강미정1, 손송이2, 이후장2
1의령고등학교
2경상대학교 수의과대학 생명과학연구소
Abstract
In the present study, the effects of different photoperiods on stress, immunity, and hematological parameters in ICR mice were evaluated. Fifty male ICR mice 7 weeks old (body weight, $27.3{pm}2.5g$) were divided into five groups: DP-0 (0/24-h light/dark cycle), DP-6 (6/18-h light/dark cycle), DP-12 (12/12-h light/dark cycle), DP-18 (18/6-h light/dark cycle), and DP-24 (24/0-h light/dark cycle). During the experimental period, no significant differences in body weight or feed intake were observed between the groups. Hematological analysis revealed that white blood cell, red blood cell, and hemoglobin values for the DP-0 group were significantly different compared to those of the other groups. After 28 days, no significant difference in serum cortisol concentration was observed among the groups, but serum cortisol levels increased in a light exposure-dependent manner. Total serum immunoglobulin G (IgG) concentrations of the DP-0 and PD-6 groups were significantly increased compared to those of the other groups (p < 0.05), and serum total IgG levels decreased in a light exposure-dependent manner. Results of the present study indicated that various photoperiods affect hematological parameters and total serum IgG levels in ICR mice while having no significant effects on body weight, feed intake, or cortisol levels.
Key Words: cortisol, hematological parameters, ICR mice, IgG, photoperiod


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