| Establishment of a live vaccine strain against fowl typhoid and paratyphoid |
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Sun-Hee Cho1, Young-Jin Ahn1, Tae-Eun Kim1, Sun-Joong Kim1, Won Huh2, Young-Sik Moon2, Byung-Hyung Lee2, Jae-Hong Kim3, Hyuk Joon Kwon4 |
1BioPOA Co.
2Daesung Microbiological Lab. Co.
3Laboratorie of Avian Diseases, College of Veterinary Medicine, Seoul National University
4Laboratorie of Poultry Production Medicine, College of Veterinary Medicine, Seoul National University |
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| Abstract |
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To develop a live vaccine strain against fowl typhoid and paratyphoid caused by Salmonella serovar Gallinarum biovar Gallinarum (Salmonella Gallinarum) and Salmonella serovar Enteritidis (Salmonella Enteritidis), respectively, several nalidixic acid resistant mutants were selected from lipopolysaccharide (LPS) rough strains of Salmonella Gallinarum that escaped from fatal infection of a LPS-binding lytic bacteriophage. A non-virulent and immunogenic vaccine strain of Salmonella Gallinarum, SR2-N6, was established through in vivo pathogenicity and protection efficacy tests. SR2-N6 was highly protective against Salmonella Gallinarum and Salmonella Enteritidis and safer than Salmonella Gallinarum vaccine strain SG 9R in the condition of protein-energy malnutrition. Thus, SR2-N6 may be a safe and efficacious vaccine strain to prevent both fowl typhoid and paratyphoid. |
| Key Words:
attenuation, fowl typhoid, live vaccine, paratyphoid, rough strain |
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