Korean J Vet Res > Volume 56(1); 2016 > Article
Korean Journal of Veterinary Research 2016;56(1):23-28.
DOI: https://doi.org/10.14405/kjvr.2016.56.1.23    Published online May 2, 2016.
Genetic diversity of nucleocapsid genes of recent porcine epidemic diarrhea viruses isolated in Korea
Kiju Kim1, Yookyung Park1, Bokyung Park1, Quang Lam Truong1, Soyeon Park1, Jaehun Kim2, Tae-Wook Hahn1
1College of Veterinary Medicine & Institute of Veterinary Science, Kangwon National University
2College of Veterinary Medicine, Jeju National University
최근 국내에서 유행하는 돼지 유행성 설사 바이러스 nucleocapsid 유전자의 다양성 및 계통 분석
김기주1, 박유경1, 박보경1, 람쯩꽝1, 박소연1, 김재훈2, 한태욱1
1강원대학교 수의과대학 및 동물의학종합연구소
2제주대학교 수의과대학
Abstract
Porcine epidemic diarrhea virus (PEDV), a porcine enteropathogenic coronavirus, causes lethal watery diarrhea in piglets, resulting in large economic losses because of high mortality. In November 2013, PEDV reemerged in Korea, and these outbreaks have since continuously occurred. In the present study, we determined the full-length nucleocapsid (N) gene sequences of three Korean PEDV field isolates collected in 2014-2015. Sequence and phylogenetic analysis of N genes revealed that recent prevalent Korean PEDV isolates were very closely related to the US PEDV isolates in 2013. Interestingly, the phylogenetic tree based on the nucleotide sequencing of the PEDV N gene was similar to the tree topology of the PEDV complete genomes. Therefore, our data provide a better understanding of the genetic diversity and contribute to the accurate diagnosis and development of vaccines against PEDV.
Key Words: Korean isolates, N gene, nucleocapsid, porcine epidemic diarrhea virus, phylogenetic analysis


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