| Hair growth promoting effects of emodin in telogenic C57BL/6 mice |
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Jung-Min Yon1, Seul Gi Park1, Chunmei Lin2, Lee Wha Gwon1, Jong-Geol Lee1, In-Jeoung Baek3, Beom Jun Lee1, Young Won Yun1, Sang-Yoon Nam1 |
1College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University
2College of Chinese Medicinal Materials, Jilin Agricultural University
3Asan Institute for Life Sciences, University of Ulsan College of Medicine |
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| Abstract |
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Emodin is an anthraquinone derivative from the roots of Rheum officinale Baill that possesses a variety of biological activities, including inhibition of $5{alpha}$-reductase and prostaglandin D2. In this study, we investigated whether emodin promotes hair growth. After emodin was topically applied to the shaved dorsal skin of telogenic C57BL/6 N mice, the hair growth rate and morphological analysis were evaluated in dorsal skin for 15 days. After 13 days of treatment, minoxidil or emodin (0.01% or 0.1%)-treated groups showed remarkable regrowth of hairs relative to the vehicle control group. Scoring of the hair growth and rate of hair growth area for 15 days revealed that groups treated with minoxidil and 0.1% emodin were significantly higher than the vehicle control group. Histological examination revealed the emodin and minoxidil groups markedly recovered the number and morphology of hair follicles, including the subcutis depth, relative to the vehicle group. These results suggest that emodin has an excellent promoting effect in hair growth similar to that of minoxidil and might be useful for treatment of baldness or alopecia. |
| Key Words:
C57BL/6 mice, alopecia, emodin, hair growth |
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