Korean J Vet Res > Volume 56(2); 2016 > Article
Korean Journal of Veterinary Research 2016;56(2):117-120.
DOI: https://doi.org/10.14405/kjvr.2016.56.2.117    Published online July 7, 2016.
Appearance of osteoporosis in rat experimental autoimmune encephalomyelitis
Meejung Ahn1, Sohi Kang2, Channam Park3, Jeongtae Kim4, Kyungsook Jung5, Miyoung Yang6, Sung-Ho Kim2, Changjong Moon2, Taekyun Shin3
1School of Medicine, College of Veterinary Medicine, Jeju National University
2Department of Veterinary Anatomy, College of Veterinary Medicine, Chonnam National University
3Department of Veterinary Anatomy, College of Veterinary Medicine, Jeju National University
4Department of Molecular Anatomy, School of Medicine, University of the Ryukyus
5Korea Research Institute of Bioscience and Biotechnology, Korea Research Institute of Bioscience and Biotechnology
6Department of Anatomy, School of Medicine, Wonkwang University
Abstract
Experimental autoimmune encephalomyelitis (EAE) in Lewis rats is characterized by transient paralysis followed by recovery. To evaluate whether transient paralysis in EAE affects bone density, tibiae of EAE rats were morphologically investigated using micro-computed tomography and histology. The parameters of bone health were significantly reduced at the peak stage of EAE rats relative to those of controls (p < 0.05). The reduction of bone density was found to remain unchanged, even in the recovery stage. Collectively, the present data suggest that osteoporosis occurs in paralytic rats with monophasic EAE, possibly through the disuse of hindlimbs and/or autoimmune inflammation.
Key Words: autoimmunity, experimental autoimmune encephalomyelitis, micro-computed tomography, osteoporosis


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