| Cardiocirculatory, biochemical and hemostatic evaluation of dogs with hyperadrenocorticism at diagnosis and after treatment |
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Frederico Aecio Carvalho Soares1, Juliana Pereira Matheus2, Guilherme Luiz Carvalho2, Elisa Barp Neuwald2, Alan Gomes Poppl2, Stella Faria Valle2, Felix Hilario Diaz Gonzalez2 |
1School of Veterinary Medicine, Centro Universitario Ritter dos Reis-UniRitter
2Department of Veterinary Clinical Pathology, School of Veterinary Medicine, Universidade Federal do Rio Grande do Sul |
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| Abstract |
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Hyperadrenocorticism (HAC) is a common endocrinopathy among dogs that causes multisystemic signs. This study was conducted to evaluate cardiocirculatory, biochemical, and hemostatic parameters in dogs with HAC at diagnosis, in addition to verifying whether abnormal parameters could be controlled by initial treatment with trilostane. Fifteen dogs with HAC were assessed by systolic blood pressure measurement, electrocardiography, Doppler echocardiography, serum concentration of troponin I, and biochemical and hemostatic profile at diagnosis and after trilostane therapy. Unlike biochemical parameters, hemostatic and cardiocirculatory parameters were not significantly influenced by the onset of treatment. The authors believe that clinical treatment with trilostane for 3 to 4 months might not be sufficient for the stabilization of cardiocirculatory abnormalities such as hypertension. Therefore, dogs with HAC must receive cardiocirculatory monitoring at diagnosis and during drug treatment. |
| Key Words:
canine, cardiac troponin I, cardiology, endocrinology, trilostane |
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