Korean J Vet Res > Volume 56(3); 2016 > Article
Korean Journal of Veterinary Research 2016;56(3):183-187.
DOI: https://doi.org/10.14405/kjvr.2016.56.3.183    Published online October 11, 2016.
Fermented antler extract enhances the viability and interleukin-12 production of spleen cells
Hye-Yeoul Yang1, Youngsu Kim2, Hong-Gu Joo1
1Laboratory of Veterinary Pharmacology, College of Veterinary Medicine, Jeju National University
2Malgeunsaem Korean Medicine Clinic
발효녹용 추출물에 의한 비장세포의 생존율 및 interleukin-12 생산 증진
양혜열1, 김영수2, 주홍구1
1제주대학교 수의과대학 수의약리학실
2맑은샘한의원
Abstract
The effects of antlers have long been known in traditional Asian medicine. However, few studies have investigated the effects of antlers on immunity. In this study, we investigated whether fermented antler extract (FAE) has immunomodulatory effects on spleen cells. FAE enhanced the activity of spleen cells in a concentration dependent manner compared to antler extract. Interestingly, FAE significantly increased the production of interleukin-12, a representative cytokine of cell-mediated immunity, while it marginally increased that of tumor necrosis factor-alpha. Flow cytometry analysis demonstrated that FAE can protect spleen cells from spontaneous cell death without a significant proportional change in subsets, mainly lymphocytes. Taken together, the results of the present study showed that FAE has beneficial effects on spleen cells, a major type of immune cell, indicating that it can function as an immunomodulator without significant cytotoxicity. These data may broaden the use of FAE in basic research and clinical areas.
Key Words: fermented antler extract, immunomodulation, spleen cells
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