| Hangover relieving effect of Sanghwang mushroom mycelium extract |
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Min-Su Kim1, Yoo-Jin An1, Jae-Chul Lee1, Ga-Ryoung Park1, Dong Soo Park2, Nam Gen Jeon2, Youngjae Lee1, Chang-Hoon Han1 |
1College of Veterinary Medicine, Jeju National University
2Jeju Sanghwang Co., Ltd. |
| 상황버섯 균사체 추출물의 숙취해소 효과에 관한 연구 |
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김민수1, 안유진1, 이재철1, 박가령1, 박동수2, 전남근2, 이영재1, 한창훈1 |
1제주대학교 수의과대학 수의학과
2(주)제주상황 |
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| Abstract |
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This study was conducted to evaluate the hangover relieving effect of Sanghwang mushroom mycelium extract (SME). The extract showed 1,1-diphenyl-2-picrylhydrazyl radical scavenging effect in a concentration-dependent manner and high antioxidant capacity ($56.67{pm}1.77%$) when administered at $120{mu}g/mL$. In addition, SME significantly increased (p < 0.005) the aldehyde dehydronase (ALDH) activity ($126.03{pm}9.11%$) when applied at 8 or $16{mu}L/mL$. A locomotor activity test showed that the alcohol-water treated group showed significantly decreased motor activity at 90 min post-administration. However, the alcohol-SME treated group showed a 20-fold higher motor activity than that observed in the alcohol-water treated group at 90 min post-administration. Blood was harvested from each mouse at 90 min post-administration, and both alcohol and aldehyde concentrations were measured. The alcohol-SME treated group showed significantly lower (p < 0.5) alcohol ($120.13{pm}12.83{mu}g/mL$) and aldehyde ($7.26{pm}1.22{mu}g/mL$) concentrations than the values observed in the alcohol-water treated group. These results suggest that the hangover relieving effect of SME results from increased ALDH activity, which reduces the aldehyde concentration in the blood. |
| Key Words:
blood aldehyde concentration, hangover relieving effect, locomotor activity test, Sanghwang mushroom mycelium extract |
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