Korean J Vet Res > Volume 56(4); 2016 > Article
Korean Journal of Veterinary Research 2016;56(4):241-247.
DOI: https://doi.org/10.14405/kjvr.2016.56.4.241    Published online February 27, 2017.
Hangover relieving effect of Sanghwang mushroom mycelium extract
Min-Su Kim1, Yoo-Jin An1, Jae-Chul Lee1, Ga-Ryoung Park1, Dong Soo Park2, Nam Gen Jeon2, Youngjae Lee1, Chang-Hoon Han1
1College of Veterinary Medicine, Jeju National University
2Jeju Sanghwang Co., Ltd.
상황버섯 균사체 추출물의 숙취해소 효과에 관한 연구
김민수1, 안유진1, 이재철1, 박가령1, 박동수2, 전남근2, 이영재1, 한창훈1
1제주대학교 수의과대학 수의학과
This study was conducted to evaluate the hangover relieving effect of Sanghwang mushroom mycelium extract (SME). The extract showed 1,1-diphenyl-2-picrylhydrazyl radical scavenging effect in a concentration-dependent manner and high antioxidant capacity ($56.67{pm}1.77%$) when administered at $120{mu}g/mL$. In addition, SME significantly increased (p < 0.005) the aldehyde dehydronase (ALDH) activity ($126.03{pm}9.11%$) when applied at 8 or $16{mu}L/mL$. A locomotor activity test showed that the alcohol-water treated group showed significantly decreased motor activity at 90 min post-administration. However, the alcohol-SME treated group showed a 20-fold higher motor activity than that observed in the alcohol-water treated group at 90 min post-administration. Blood was harvested from each mouse at 90 min post-administration, and both alcohol and aldehyde concentrations were measured. The alcohol-SME treated group showed significantly lower (p < 0.5) alcohol ($120.13{pm}12.83{mu}g/mL$) and aldehyde ($7.26{pm}1.22{mu}g/mL$) concentrations than the values observed in the alcohol-water treated group. These results suggest that the hangover relieving effect of SME results from increased ALDH activity, which reduces the aldehyde concentration in the blood.
Key Words: blood aldehyde concentration, hangover relieving effect, locomotor activity test, Sanghwang mushroom mycelium extract

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