Korean J Vet Res > Volume 57(2); 2017 > Article
Korean Journal of Veterinary Research 2017;57(2):105-111.
DOI: https://doi.org/10.14405/kjvr.2017.57.2.105    Published online August 11, 2017.
Comparative in vivo biodistributions of nanoparticles and polymers of 177lutetium-labeled hyaluronic acids in mice during 28 days
Chunmei Lin1, Ju-Yeon Jeong2, Jung-Min Yon3, Seul Gi Park2, Lee Wha Gwon2, Jong-Geol Lee2, In-Jeoung Baek4, Sang-Soep Nahm5, Beom Jun Lee2, Young Won Yun2, Sang-Yoon Nam2
1College of Chinese Medicinal Materials, Jilin Agricultural University
2College of Veterinary Medicine and Veterinary Medical Center, Chungbuk National University
3Division of Biosafety Evaluation and Control, Centers for Disease Control & Prevention
4Asan Institute for Life Sciences, Asan Medical Center and University of Ulsan
5College of Veterinary Medicine, Konkuk University
Hyaluronic acid (HA) has been investigated for biomedical and pharmaceutical applications. This study was conducted to determine the distributions of HA nanoparticles (NPs; size 350-400 nm) and larger HA polymers in mice at intervals after application. $^{177}Lutetium$ (Lu)-labeled HA-NPs or HA polymers were intravenously injected (5 mg/kg) into male ICR mice, and radioactivity levels in blood and target organs were measured from 0.25 h to 28 days post-injection. In blood, the radioactivities of HA-NPs and HA polymer peaked at 0.5 h after injection but were remarkably decreased at 2 h; subsequently, they maintained a constant level until 6 days post-injection. HA-NPs and HA polymers were observed in the liver, spleen, lung, kidney, and heart (in ascending order) but were seldom observed in other organs. After 3 days, both the HA-NP and HA polymer levels showed similar steady decreases in lung, kidney, and heart. However, in liver and spleen, the HA-NP levels tended to decrease gradually after 1 day and both were very low after 14 days, whereas the HA polymer level accumulated for 28 days. The results indicate that HA-NPs, with their faster clearance pattern, may act as a better drug delivery system than HA polymers, especially in the liver and spleen.
Key Words: drug delivery system, hyaluronic acid, in vivo biodistribution, nanoparticle, $^{177}Lutetium$

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