Korean J Vet Res > Volume 57(3); 2017 > Article
Korean Journal of Veterinary Research 2017;57(3):175-180.
DOI: https://doi.org/10.14405/kjvr.2017.57.3.175    Published online November 27, 2017.
Evaluation of safety and immunogenicity of a new octavalent inactivated vaccine containing porcine parvovirus, erysipelas, and leptospira
Kiju Kim1, Jong-Young Choi1, Su-Jin Park2, Tae-Wook Hahn1
1College of Veterinary Medicine & Institute of Veterinary Science, Kangwon National University
2Zoetis Korea
돼지 파보바이러스, 단독 및 렙토스피라 8가 불활화 백신의 안전성 및 면역원성 평가
김기주1, 최종영1, 박수진2, 한태욱1
1강원대학교 수의과대학 및 동물의학종합연구소
2조에티스 코리아
Porcine parvovirus, Erysipelothrix (E.) rhusiopathiae, and Leptospira (L.) interrogans are considered major etiologic agents of reproductive failure in pigs, causing economic loss in the swine industry. In this study, the safety and immunogenicity of a new octavalent inactivated vaccine were evaluated. The vaccine contained inactivated porcine parvovirus, E. rhusiopathiae, and six L. interrogans serovars (Bratislava, Canicola, Grippotyphosa, Hardjo, Icterohaemorrhagiae, and Pomona). Safety test results showed no notable side effects or clinical signs after vaccination in mice, guinea pigs, and sows. In addition, we assessed immunogenicity of the vaccine in 25 sows under field conditions. The vaccinated group (n = 20) had a significantly higher antibody level than the non-vaccinated group (n = 5). Moreover, the stillbirth rate decreased in piglets born from vaccinated sows, resulting in an increased fertility rate. The results of this study demonstrate that the new octavalent inactivated vaccine can be applied safely and effectively to improve reproductive performance in sows.
Key Words: erysipelas, leptospirosis, porcine parvovirus, swine, vaccine

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