| Effects of dietary acetaminophen and vitamin C supplement on serum cortisol and tumor necrosis factor-alpha concentrations in pigs vaccinated with foot-and-mouth disease vaccine |
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Chun-Nam Cha1, Beom-Jun Lee2, Eun-Kee Park3, Chang-Yeol Yoo4, Suk Kim5, Hu-Jang Lee5 |
1Engineering Research Institute and Department of Industrial Systems Engineering, Gyeongsang National University
2College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University
3Department of Medical Humanities and Social Medicine, College of Medicine, Kosin University
4Department of Computer Information, Gyeongnam Provincial Namhae College
5College of Veterinary Medicine and Institute of Animal Medicine, Gyeongsang National University |
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| Abstract |
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This study evaluated the effect of a combination of acetaminophen and vitamin C (CAV) on reducing serum cortisol and tumor necrosis $factor-{alpha}$ ($TNF-{alpha}$) concentrations in piglets vaccinated with foot-and-mouth disease (FMD) vaccine. Piglets were vaccinated with FMD vaccine and treated with CAV at concentrations of 0.0, 0.5, 1.0, and 2.0 kg/ton feed (P-CON, AD-1, AD-2, and AD-3, groups, respectively) for 5 days post-vaccination. Cortisol and $TNF-{alpha}$ levels at 5 days post-treatment in the AD-1-3 groups were significantly lower than that in the P-CON group (p < 0.05). There were no significant differences between AD-2 and AD-3 groups and non-vaccinated, non-CAV-treated piglets. |
| Key Words:
acetaminophen, cortisol, foot-and-mouse disease vaccination, pigs, tumor necrosis factor-alpha |
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