Evaluation of the efficacy of an attenuated live vaccine based on virulent porcine reproductive and respiratory syndrome virus 2 in young pigs

Lee, Seung-Chul; Noh, Yun-Hee; Lee, Sunhee; Choi, Hwan-Won; Yoon, In-Joong; Kang, Shien-Young; Lee, Changhee

doi:2018.58.3.137

Korean J Vet Res > Volume 58(3); 2018 > Article

Brief Communication

Korean Journal of Veterinary Research 2018;58(3):137-141.
DOI: https://doi.org/10.14405/kjvr.2018.58.3.137 Published online October 11, 2018.

Evaluation of the efficacy of an attenuated live vaccine based on virulent porcine reproductive and respiratory syndrome virus 2 in young pigs

Seung-Chul Lee¹, Yun-Hee Noh¹, Sunhee Lee², Hwan-Won Choi¹, In-Joong Yoon¹, Shien-Young Kang³, Changhee Lee²

¹Choong Ang Vaccine Laboratories Co., Ltd.
²Animal Virology Laboratory, School of Life Sciences, BK21 Plus KNU Creative BioResearch Group, Kyungpook National University
³College of Veterinary Medicine, Chungbuk National University

Abstract

The efficacy of the CA-2-MP120 vaccine, a cell culture-attenuated strain of virulent porcine reproductive and respiratory syndrome virus (PRRSV), was assessed in pigs. Despite the persistence of viremia in all vaccinated animals during the immunization period, the virus was not detected in vaccinated pigs following challenge. Furthermore, no pigs in the vaccinated group shed PRRSV nasally, orally or rectally throughout the experiment. Moreover, histopathological lung and lymph node lesions in the immunized group were much milder than those in the unimmunized and challenged group. These results indicated that CA-2-MP120 can provide effective protection against virulent wild-type PRRSV-2.

Key Words: attenuated vaccines, porcine reproductive and respiratory syndrome virus, treatment outcome, vaccination