Korean J Vet Res > Volume 58(3); 2018 > Article
Korean Journal of Veterinary Research 2018;58(3):137-141.
DOI: https://doi.org/10.14405/kjvr.2018.58.3.137    Published online October 11, 2018.
Evaluation of the efficacy of an attenuated live vaccine based on virulent porcine reproductive and respiratory syndrome virus 2 in young pigs
Seung-Chul Lee1, Yun-Hee Noh1, Sunhee Lee2, Hwan-Won Choi1, In-Joong Yoon1, Shien-Young Kang3, Changhee Lee2
1Choong Ang Vaccine Laboratories Co., Ltd.
2Animal Virology Laboratory, School of Life Sciences, BK21 Plus KNU Creative BioResearch Group, Kyungpook National University
3College of Veterinary Medicine, Chungbuk National University
The efficacy of the CA-2-MP120 vaccine, a cell culture-attenuated strain of virulent porcine reproductive and respiratory syndrome virus (PRRSV), was assessed in pigs. Despite the persistence of viremia in all vaccinated animals during the immunization period, the virus was not detected in vaccinated pigs following challenge. Furthermore, no pigs in the vaccinated group shed PRRSV nasally, orally or rectally throughout the experiment. Moreover, histopathological lung and lymph node lesions in the immunized group were much milder than those in the unimmunized and challenged group. These results indicated that CA-2-MP120 can provide effective protection against virulent wild-type PRRSV-2.
Key Words: attenuated vaccines, porcine reproductive and respiratory syndrome virus, treatment outcome, vaccination

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