| Anti-influenza properties of herbal extract of Althaea rosea in mice |
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Myun Soo Kim1, Kiramage Chathuranga2, Hongik Kim1, Jong-Soo Lee2, Chul-Joong Kim2 |
1R&D Division, VITABIO Inc.
2College of Veterinary Medicine, Chungnam National University |
| 촉규근 추출물에 의한 항인플루엔자 효능 |
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김면수1, 차투랑가기라마게2, 김홍익1, 이종수2, 김철중2 |
1(주)비타바이오
2충남대학교 수의과대학 |
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| Abstract |
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Althaea rosea has been used in traditional Chinese medicine to treat numerous diseases, but no studies have investigated its anti-influenza properties to date. In this study, we investigated the anti-influenza effects of Althaea rosea. BALB/c mice orally pretreated with Althaea rosea ($200{mu}L$, 0.1 mg/mL concentration in phosphate-buffered saline) and followed by infection of influenza A virus nasally showed higher survivability and lower lung virus titer against divergent subtypes of influenza A virus infection. We also found that oral administration of Althaea rosea elicited antiviral innate immune responses in serum, bronchoalveolar lavage fluid, small intestinal fluid, and the lungs. Taken together, these findings suggest that aqueous extracts of Althaea rosea are a potential candidate for use as an anti-influenza drug. |
| Key Words:
Althaea rosea, antivial agents, influenza A virus, interferon inducers, medicinal plant |
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