Nailbed malignant melanoma in three dogs

Jo, Hyoung-Nam; Suh, Myeong-Won; Lee, Joo-Ok; Kim, Jae-Hoon

doi:2019.59.4.219

Korean J Vet Res > Volume 59(4); 2019 > Article

Case report

Korean Journal of Veterinary Research 2019;59(4):219-222.
DOI: https://doi.org/10.14405/kjvr.2019.59.4.219 Published online February 17, 2020.

Nailbed malignant melanoma in three dogs

Hyoung-Nam Jo¹, Myeong-Won Suh¹, Joo-Ok Lee², Jae-Hoon Kim¹

¹College of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University
²Ekklim Anima Hospital

Correspondence: Jae-Hoon Kim, Tel: 82-64-754-3387, Fax: 82-64-702-9920,
Email: kimjhoon@jejunu.ac.kr

Abstract

Three 8-12-year-old male cocker spaniels presented with an appendicular mass accompanied by pain, inflammation, lameness, and loss of nail in the digits of the forelimb or hindlimb. A histological examination revealed dermal masses of the digit composed of numerous neoplastic cells with marked pleomorphism and high mitosis. The neoplastic cells showed a strong invasive tendency into the epidermis and adjacent bony tissues, such as distal phalanx. Immunohistochemistry of the neoplastic cells in three masses revealed positive reactions for Melan-A. These three dogs were diagnosed as nailbed malignant melanoma in the digit based on the history, clinical signs, and histopathologic features.

Key Words: digit, distal phalanx, dog, Melan-A, nailbed malignant melanoma